Both forwards were forced off in the second half of last weekend’s 2-2 draw with Arsenal after Maddison had assisted both Son’s equalisers.
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Brennan Johnson misses the game, having pulled up with a suspected hamstring injury in the second half at the Emirates.
Postecoglou opts to use Richarlison through the middle and move Son wide left.
Youngster Jamie Donley has a place on the bench after impressing for the Under-21s.
Confirmed team news
Predicted Tottenham XI (4-2-3-1): Vicario; Porro, Romero, van de Ven, Udogie; Sarr, Bissouma; Kulusevski, Maddison, Son; Richarlison
Injuries: Bentancur, Perisic, Gil, Sessengon, Johnson
Time and date: 5.30pm BST on Saturday 30 September, 2023
Venue: Tottenham Hotspur Stadium
TV channel and live stream: Sky Sports