Sputnik V shows strong protection against Omicron: Joint Italian-Russian study

The Gamaleya National Research Center of Epidemiology and Microbiology (Gamaleya Center) and the Russian Direct Investment Fund on Thursday said that 2 doses of Sputnik V provide more than 2 times higher geometric mean titers (GMT) of virus neutralising antibodies to the Omicron variant of Covid than 2 doses of Pfizer vaccine (2.1 times higher in total and 2.6 times higher 3 months after vaccination).A

The study was conducted at the leading Italian research institute for infectious diseases, by a joint Italian-Russian team of researchers representing the Institute and the Gamaleya Center in the equal laboratory conditions on comparable sera samples from individuals vaccinated with Sputnik V and Pfizer with a similar level of IgG antibodies and virus neutralising activity (VNA) against Wuhan variant, said a report.

Among the top quartile of individuals with high RBD-specific IgG antibodies, 100 per cent of those vaccinated with Sputnik V were able to neutralise Omicron variant in comparison to 83.3 per cent of individuals vaccinated with Pfizer. Among all samples, 74.2 per cent of Sputnik V-vaccinated sera were able to neutralise Omicron vs 56.9 per cent for Pfizer-vaccinated, it said.

Alexander Gintsburg, Director of the National Research Center for Epidemiology and Microbiology, said: “The joint study by the Gamaleya Center and Spallanzani Institute confirmed the results obtained in our separate study published in December 2021. The hard scientific data proves Sputnik V has higher virus neutralising activity against Omicron as compared to other vaccines and will play a major role in the global fight against this new contagious variant.”

“Results of the study in Italy confirm Sputnik V offers the strongest protection against Omicron. The adenoviral platform has shown high efficacy in fighting mutations of Covid previously. Partnership of different platforms is the key and heterologous (‘mix & match’) boosting with Sputnik Light will help strengthen efficacy of other vaccines in light of combined Delta and Omicron challenge,” said Kirill Dmitriev, CEO of RDIF.

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