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Scientist Say a cutting-edge gene-editing Treatment Can help people cut harmful highs cholesterol Level half – after only one treatment.
a small one tests In 15 people with high cholesterol, significant reductions in two major risk factors were seen, despite taking traditional, lifelong medications to lower it. heart disease After receiving a single gene-editing treatment at the highest dose.
experimental Medicine Use crisperA gene editing tool that allows scientists to make changes dnaIn this case, the drug targeted a gene called ANGPTL3 in the liver to reduce LDL, or “bad” cholesterol, and triglycerides, both of which are linked. Heart Disease.
“We’ve never had anything that can reduce both LDL and triglycerides by nearly 50 percent,” said Cleveland Clinic cardiologist Dr. Steven Nissen, lead researcher on the therapy’s first-human study.
The results of the study were presented and published Saturday at the American Heart Association annual meeting The New England Journal of Medicine.
According to the research, cholesterol and triglyceride levels began to decrease in participants within two weeks of receiving the treatment and the results persisted for at least 60 days.
Although this trial was small, future successful trials could be life-changing for many people, according to the scientists behind the study.
“Instead of a once-daily pill or monthly injection, this therapy would potentially provide a one-time infusion that is safe and sustainable patients With high cholesterol,” said study co-leader, Dr. Luke Laffin of the Cleveland Clinic.
High LDL, the “bad” cholesterol, can cause plaque to build up in the artery walls, increasing the risk of heart attack or stroke. Meanwhile, high triglycerides, another blood fat, can also increase those risks.
The 15 trial participants were from Australia, New Zealand and the UK and were all aged between 50 and 60. Thirteen of the participants were men and all had uncontrolled high cholesterol, triglycerides, or both.
“We’re going to try to demonstrate the safety and efficacy of these one-to-one treatments because we think these options are important for patients,” Nissen said.
Three participants had temporary reactions to therapy, including nausea and increased liver enzymes; However, their reactions resolved immediately, the scientists said.
With reporting from Reuters.