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long term use Common antacid drugscalled proton pump inhibitors (PPIs), may not increase the risk of: stomach cancerA new study suggests this could bring relief to millions of patients.
These widely prescribed drug Treat similar situations Acid reflux and ulcersbut has been subject to concerns about cancer since its introduction in the 1980s, with some previous Research Represents a link.
However, the researchers behind the latest study published in the British Medical Journal, consider early work “Hindered by several methodological limitations, making this possible association uncertain.”
They aim to solve these problems by examining all data Stomach and esophageal cancer Patients in Denmark, Norway, Finland, Iceland and Sweden between 1994 and 2000.
The extensive study, led by experts at Sweden’s Karolinska Institute, compared more than 17,000 people diagnosed with the condition stomach cancer Compare that to 170,000 people who don’t have the disease. The study found that 10% of cancer patients and 9.5% of control patients were on long-term PPI use (defined as more than one year).
“No association was found between long-term proton pump inhibitor use and gastric adenocarcinoma,” the authors concluded. They suggested that previous studies may have been biased by using proton pump inhibitors shortly before diagnosis, focusing on short-term prescriptions, or failing to account for other variables.
“This finding should provide relief for patients requiring long-term proton pump inhibitor therapy and be valuable for clinical decision-making in healthcare settings,” the authors said.
Still, they warn, “long-term use of proton pump inhibitors may cause side effects and increase the risk of other potentially serious conditions, such as Clostridium difficile-associated diarrhea, osteoporosis, and vitamin or electrolyte malabsorption.”
2025, the scientist from international agencies Research The World Health Organization’s Agency for Research on Cancer (IARC) estimates that if current trends continue, approximately 15.6 million people born between 2008 and 2017 will be diagnosed with stomach cancer in their lifetime.
Of these cases, a staggering 11.9 million (76%) were directly related to Helicobacter pylori (H. pylori) infection.
While the vast majority of new cases will occur in Asia (especially India and China), approximately 2 million may occur in America1.7 million Africa Europe has 1.2 million.