It’s ten years Brazil Had to face a big outbreak of Zika virusThe alert was given in 2015, when the north-eastern states of the country reported a sudden increase in the number of infants born with unusually small heads-a status called a microcefly.
Obsthetrician Adriana was working in a maternity ward in Mello Paraba when she saw something strange during regular ultrasound. More and more fetuses were microcephorial. He suspected a link Zika The virus, which begins to broadcast only in Brazil.
Mello collected amniotic fluid samples and sent them for testing. The results confirmed her suspicion, allowing her to prove that zika infection in pregnancy can cause severe brain malformations. The discovery was important for both Brazil and International Health Officers and triggered a global effort to control the epidemic.
Research in Zika, a decade, has moved forward. Scientists have long studied how the virus damages the developing brain, but till now its effects on the adult brain were less pronounced.
With Gisle Pasos and Iranaya Asunko-Miranda from Rio de Janeiro’s Federal University, Grande Do Sule and Walnberg Center for Mallicular Medicine with Grande Do Sule and Walnberg Center for Mallicular Medicine, we have come to know that Zika can also infect Hypeothalam and Hypothalamus. Insulin,
How Zika attacks the brain
Hypothalamus is a small but important part of the brain that helps control things such as appetite, temperature, heart rate and metabolism. In our study, we found that Zika reaches the hypothalamus and triggers inflammation, activates immune cells called microglia in the brain and how insulin works, causing persistent problems with it. Insulin helps the body to control blood sugar, so it can happen when it does not work properly Type 2 diabetes,
Our research, which was recently accepted for publication in Journal Cell Death and Disease, indicates that even after inflammation, insulin resistance of the brain persists.
In experiments on adult mice, zika infection led a strong immune response in the hypothalamus and inhibit the balance of hormones regulating blood sugar. These results suggest that people who have zika may have a high risk of metabolic problems for a long time even after recovering from early infections.
About authors
Julia Clarke, Coordinator and Associate Professor, Federal University of Rio de Janeiro (UFRJ), Coordinator and Associate Professor of Neuroprograming Research Laboratory.
Claudia Pinto Figuardo, Associate Professor at Carlos Chugas Filh Institute of Biofizics, Federal University of Rio de Janeiro (UFRJ).
This article has been reinstated Conversation Under a Creative Commons License. read the Original article,
It fits with what we know about Zika and other viruses. Iska is from Flavividarde Family, including dengue, another mosquito -borne virus. Previous studies have shown that zika can damage both developing and adult brain, causing a condition such as mylitis or encephalomyelitis. Research in mice shows that zika can remain in the hypothalamus, affects the hormone system that controls growth and reproduction, and even reduces fertility.
Similar disruption in insulin signaling has also been seen with other viral infections, which include influenza, kovid, HIV, hepatitis C and dengue. This highlights the importance of closely monitoring of viral outbreaks and their potential long -term effects on health.
Our findings suggest that zika infection should now be considered not only as an immediate risk for developing fetus, but should also be considered as a potential contributor to metabolic problems like Type 2 diabetes In adults.
Better understanding how zika adult affects the brain, we can eventually develop strategy to prevent or reduce these long -term results and be better prepared for future viral outbreaks.