What are GLP-3 weight loss pills?

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Eli Lilly and Company Announced in December Its next-generation weight loss drug retarglutide In late-stage trials, it helped patients lose more weight than any other similar weight-loss drug.

Patient taking once-weekly drug for 68 weeks dies Nearly 29% of body weightwhile patients take Semaglutide medications, such as Ozempic or before Wegovy Only lost 16%.

But retarglutide works differently than other popular drugs.

That’s because it’s a triple hormone receptor agonist. rather than just targeting and stimulating one hormone Help suppress appetite Like GLP drugs that make you feel fuller, retarglutide has three goals.

Some people now refer to retarglutide as “GLP-3.”

The popular weight-loss drug suppresses appetite by targeting the GLP-1 hormone. Now, Eli Lilly's new vaccine targeting more hormones has been shown to be more effective — The popular weight-loss drug suppresses appetite by targeting the GLP-1 hormone. Now, Eli Lilly’s new vaccine targeting more hormones has been shown to be more effective (Getty Images/iStock)

What is GLP-3? How does it work?

According to reports, semaglutide weight loss drug works by mimicking the hormone GLP-1, also known as glucagon-like peptide cleveland clinic. These drugs do this by activating hormone-producing proteins in the brain.

GLP-1 helps regulate blood sugar, reduces appetite, and slows digestion.

retarglutide Works by mimicking three different hormones: GLP-1, GIP, and glucagon.

GIP (glucose-dependent insulinotropic polypeptide) works synergistically with GLP-1 to improve the body’s metabolism and release of the blood sugar-regulating hormone insulin

Glucagon helps the body burn stored fat for fuel and reduce weight.

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Eli Lilly and Company rival Novo Nordisk Announcing licensing agreement It applied for GLP-3 drugs in March last year.

Eli Lilly and Company’s Mounjaro is the only dual drug on the market that targets GLP-1 and GIP. doctor says monzaro Also more effective than the drug semaglutideAlthough Results show less weight loss over 72 weeks.

As of March 2024, Eli Lilly's corporate headquarters campus is located in Indianapolis, Indiana. The company also produces Mounjaro — As of March 2024, Eli Lilly’s corporate headquarters campus is located in Indianapolis, Indiana. The company also produces Mounjaro (Getty Images)

Risk and reward

Experts believe the combination of these three hormones is why GLP-3 drugs may prove more effective in the future.

However, more research is needed on their safety – and they are not without risks.

Eli Lilly said more than 12% of patients in its trial of retarglutide lost so much weight and experienced other “adverse events” that they stopped taking the drug.

What’s more, more than 20 percent of people who took the highest dose of Lilly’s drug (12 milligrams) also had skin pain when touching it.

Still, most side effects are consistent with those experienced when taking weight loss drugs currently on the market, such as nausea, diarrhea, vomiting, and constipation.

One in eight Americans is taking GLP-1 drugs, according to a recent study KFF Health Tracking Poll.